Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gcg  glucagon   (Synonyms: GLP-1, Glu, glucagon-like peptide I, PPG)
Results	Reference
1	J:70719 Allen-Jennings AE, Hartman MG, Kociba GJ, Hai T, The roles of atf3 in glucose homeostasis. a transgenic mouse model with liver dysfunction and defects in endocrine pancreas. J Biol Chem. 2001 Aug 3;276(31):29507-14
1	J:156329 Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L, Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 6;284(45):31236-48
1	J:305792 Ansarullah, Jain C, Far FF, Homberg S, Wissmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenlander L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Muller TD, Meier M, Tschop MH, Coskun U, Lickert H, Inceptor counteracts insulin signalling in beta-cells to control glycaemia. Nature. 2021 Feb;590(7845):326-331
1	J:119565 Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV, Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol. 2006 Oct 15;298(2):616-31
1	J:116552 Brissova M, Shostak A, Shiota M, Wiebe PO, Poffenberger G, Kantz J, Chen Z, Carr C, Jerome WG, Chen J, Baldwin HS, Nicholson W, Bader DM, Jetton T, Gannon M, Powers AC, Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes. 2006 Nov;55(11):2974-85
1	J:255164 Broche B, Ben Fradj S, Aguilar E, Sancerni T, Benard M, Makaci F, Berthault C, Scharfmann R, Alves-Guerra MC, Duvillie B, Mitochondrial Protein UCP2 Controls Pancreas Development. Diabetes. 2018 Jan;67(1):78-84
1	J:200985 Cai EP, Wu X, Schroer SA, Elia AJ, Nostro MC, Zacksenhaus E, Woo M, Retinoblastoma tumor suppressor protein in pancreatic progenitors controls alpha- and beta-cell fate. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14723-8
1	J:129103 Chao CS, Loomis ZL, Lee JE, Sussel L, Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol. 2007 Dec 15;312(2):523-32
1	J:220324 De Vas MG, Kopp JL, Heliot C, Sander M, Cereghini S, Haumaitre C, Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors. Development. 2015 Mar 1;142(5):871-82
1	J:119284 Decker K, Goldman DC, Grasch CL, Sussel L, Gata6 is an important regulator of mouse pancreas development. Dev Biol. 2006 Oct 15;298(2):415-29
1	J:209744 Diaferia GR, Cirulli V, Biunno I, SEL1L regulates adhesion, proliferation and secretion of insulin by affecting integrin signaling. PLoS One. 2013;8(11):e79458
1	J:119914 Doyle MJ, Loomis ZL, Sussel L, Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development. 2007 Feb;134(3):515-23
1	J:141158 Fontaniere S, Duvillie B, Scharfmann R, Carreira C, Wang ZQ, Zhang CX, Tumour suppressor menin is essential for development of the pancreatic endocrine cells. J Endocrinol. 2008 Nov;199(2):287-98
1*	J:152922 Golson ML, Le Lay J, Gao N, Bramswig N, Loomes KM, Oakey R, May CL, White P, Kaestner KH, Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Mech Dev. 2009 Aug-Sep;126(8-9):687-99
1*	J:191140 Grigoryan M, Kedees MH, Guz Y, Teitelman G, Phenotype of entero-endocrine L cells becomes restricted during development. Dev Dyn. 2012 Dec;241(12):1986-92
1	J:134078 Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA, Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol. 2008 Apr;28(7):2414-25
1*	J:127539 Joglekar MV, Parekh VS, Mehta S, Bhonde RR, Hardikar AA, MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3. Dev Biol. 2007 Nov 15;311(2):603-12
1	J:257425 Kim DS, Song L, Wang J, Wu H, Gu G, Sugi Y, Li Z, Wang H, GRP94 Is an Essential Regulator of Pancreatic beta-Cell Development, Mass, and Function in Male Mice. Endocrinology. 2018 Feb 1;159(2):1062-1073
1	J:112755 Kim HJ, Schleiffarth JR, Jessurun J, Sumanas S, Petryk A, Lin S, Ekker SC, Wnt5 signaling in vertebrate pancreas development. BMC Biol. 2005;3:23
1	J:306907 Kodani N, Nakae J, Kobayashi M, Kikuchi O, Kitamura T, Itoh H, FCoR-Foxo1 Axis Regulates alpha-Cell Mass through Repression of Arx Expression. iScience. 2020 Jan 24;23(1):100798
1	J:176201 Kordowich S, Collombat P, Mansouri A, Serup P, Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage. BMC Dev Biol. 2011;11:52
1	J:272578 Liu J, Banerjee A, Herring CA, Attalla J, Hu R, Xu Y, Shao Q, Simmons AJ, Dadi PK, Wang S, Jacobson DA, Liu B, Hodges E, Lau KS, Gu G, Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity. Dev Cell. 2019 Jan 7;48(1):49-63.e7
1	J:290417 Lorberbaum DS, Kishore S, Rosselot C, Sarbaugh D, Brooks EP, Aragon E, Xuan S, Simon O, Ghosh D, Mendelsohn C, Gadue P, Sussel L, Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human beta cell specification. Development. 2020 Jun 22;147(12):dev189977
1	J:63347 Maldonado TS, Kadison AS, Crisera CA, Grau JB, Alkasab SL, Longaker MT, Gittes GK, Ontogeny of activin B and follistatin in developing embryonic mouse pancreas: implications for lineage selection. J Gastrointest Surg. 2000 May-Jun;4(3):269-75
1	J:227268 Malenczyk K, Keimpema E, Piscitelli F, Calvigioni D, Bjorklund P, Mackie K, Di Marzo V, Hokfelt TG, Dobrzyn A, Harkany T, Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6185-94
1	J:62160 Miettinen PJ, Huotari M, Koivisto T, Ustinov J, Palgi J, Rasilainen S, Lehtonen E, Keski-Oja J, Otonkoski T, Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors. Development. 2000 Jun;127(12):2617-27
1*	J:130176 Nammo T, Yamagata K, Tanaka T, Kodama T, Sladek FM, Fukui K, Katsube F, Sato Y, Miyagawa J, Shimomura I, Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas. Gene Expr Patterns. 2008 Jan;8(2):96-106
1	J:253982 Norlin S, Parekh V, Edlund H, The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018 Jan 3;145(1):dev154468
1*	J:32017 Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV, PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996 Mar;122(3):983-95
1	J:246400 Paul L, Walker EM, Drosos Y, Cyphert HA, Neale G, Stein R, South J, Grosveld G, Herrera PL, Sosa-Pineda B, Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine beta-Cells. Diabetes. 2016 Mar;65(3):687-98
1	J:266255 Scavuzzo MA, Hill MC, Chmielowiec J, Yang D, Teaw J, Sheng K, Kong Y, Bettini M, Zong C, Martin JF, Borowiak M, Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis. Nat Commun. 2018 Aug 22;9(1):3356
1	J:243381 Serafimidis I, Rodriguez-Aznar E, Lesche M, Yoshioka K, Takuwa Y, Dahl A, Pan D, Gavalas A, Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. PLoS Biol. 2017 Mar;15(3):e2000949
1	J:141017 Seymour PA, Freude KK, Dubois CL, Shih HP, Patel NA, Sander M, A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol. 2008 Nov 1;323(1):19-30
1	J:338071 Sharon N, Chawla R, Mueller J, Vanderhooft J, Whitehorn LJ, Rosenthal B, Gurtler M, Estanboulieh RR, Shvartsman D, Gifford DK, Trapnell C, Melton D, A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets. Cell. 2019 Feb 7;176(4):790-804.e13
1	J:151981 Spence JR, Lange AW, Lin SC, Kaestner KH, Lowy AM, Kim I, Whitsett JA, Wells JM, Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell. 2009 Jul;17(1):62-74
1	J:147764 Svensson P, Bergqvist I, Norlin S, Edlund H, MFng is dispensable for mouse pancreas development and function. Mol Cell Biol. 2009 Apr;29(8):2129-38
1	J:186391 Tao J, Zhu M, Wang H, Afelik S, Vasievich MP, Chen XW, Zhu G, Jensen J, Ginsburg D, Zhang B, SEC23B is required for the maintenance of murine professional secretory tissues. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):E2001-9
1	J:307817 Theis A, Singer RA, Garofalo D, Paul A, Narayana A, Sussel L, Groucho co-repressor proteins regulate beta cell development and proliferation by repressing Foxa1 in the developing mouse pancreas. Development. 2021 Mar 24;148(6):dev192401
1	J:333324 Tominaga K, Sakashita E, Kasashima K, Kuroiwa K, Nagao Y, Iwamori N, Endo H, Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells. Int J Mol Sci. 2023 Jan 20;24(3)
1	J:208719 Tsai MJ, Yang-Yen HF, Chiang MK, Wang MJ, Wu SS, Chen SH, TCTP is essential for beta-cell proliferation and mass expansion during development and beta-cell adaptation in response to insulin resistance. Endocrinology. 2014 Feb;155(2):392-404
1	J:121629 Tulachan SS, Tei E, Hembree M, Crisera C, Prasadan K, Koizumi M, Shah S, Guo P, Bottinger E, Gittes GK, TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas. Dev Biol. 2007 May 15;305(2):508-521
1	J:225743 Um SH, Sticker-Jantscheff M, Chau GC, Vintersten K, Mueller M, Gangloff YG, Adams RH, Spetz JF, Elghazi L, Pfluger PT, Pende M, Bernal-Mizrachi E, Tauler A, Tschop MH, Thomas G, Kozma SC, S6K1 controls pancreatic beta cell size independently of intrauterine growth restriction. J Clin Invest. 2015 Jul 1;125(7):2736-47
1	J:342871 Xiang J, Pompetti AJ, Faranda AP, Wang Y, Novo SG, Li DW, Duncan MK, ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment. Cells. 2023 Nov 16;12(22)
1	J:174673 Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV, Context-specific {alpha}-to-{beta}-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011 Aug 15;25(16):1680-5
1	J:144661 Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR, PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab. 2006 Dec;4(6):491-7